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. 2013 Apr 4;9(4):e1003390. doi: 10.1371/journal.pgen.1003390

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© 2013 Hill et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A) Strains evolved in azole and FK506 were tested for cross-resistance to azole and the calcineurin inhibitor cyclosporin A as well as azole and the Hsp90 inhibitor geldanamycin. (B) Candidate resistance mechanisms based on specific cross-resistance profiles of strains evolved with azole and FK506. (C) Strains evolved in azole and geldanamycin were tested for cross-resistance to azole and the Hsp90 inhibitor radicicol as well as azole and the calcineurin inhibitor FK506. (D) Candidate resistance mechanisms based on specific cross-resistance profiles of strains evolved with azole and geldanamycin. GdA = geldanamycin; RAD = radicicol; and CsA = cyclosporin A.