Figure 3. Progressive rotarod deficits developed simultaneously to a lowering of exploratory activity in R6/2 mice.

Latency to fall from an accelerating rotarod against exploratory activity measured in an open field for all R6/2 mice; data points were separated into the three ages investigated, at 5, 9 and 13 weeks of age. Positive correlations were detected between these two tasks over time due to the simultaneous development of deficits in both male (r = 0.507, **p<.01) and female (r = 0.5, **p<.01) R6/2.