Table 2. Distribution frequency of VEGF-C genotypes in 426 healthy controls and 470 male oral cancer patients.

Variable	Controls (N = 426) n (%)	Patients (N = 470)n (%)	Odds ratio (95% confidence interval)	Adjusted odds ratio (95% confidence interval)
rs3775194
GG	302 (70.9%)	355 (75.5%)	1.00	1.00
GC	114 (26.8%)	110 (23.4%)	0.821 (0.606∼1.112)	0.792 (0.515∼1.219)
CC	10 (2.3%)	5 (1.1%)	0.425 (0.144∼1.258)	0.648 (0.159∼2.640)
GC+ CC	124 (29.1%)	115 (24.5%)	0.789 (0.587∼1.061)	0.781 (0.514∼1.188)
rs11947611
AA	180 (42.3%)	185 (39.4%)	1.00	1.00
AG	204 (47.9%)	227 (48.3%)	1.083 (0.819∼1.431)	1.213 (0.817∼1.802)
GG	42 (9.9%)	58 (12.3%)	1.344 (0.859∼2.101)	1.375 (0.714∼2.649)
AG+GG	246 (57.7%)	285 (60.6%)	1.127 (0.863∼1.472)	1.242 (0.853∼1.809)
rs1485766
CC	149 (35.0%)	158 (33.6%)	1.00	1.00
CA	201 (47.2%)	209 (44.5%)	0.981 (0.729∼1.318)	0.873 (0.571∼1.336)
AA	76 (17.8%)	103 (21.9%)	1.278 (0.882∼1.853)	1.153 (0.672∼1.979)
CA+AA	277 (65.0%)	312 (66.4%)	1.062 (0.806∼1.400)	0.946 (0.635∼1.411)
rs7664413
CC	246 (57.7%)	248 (52.8%)	1.00	1.00
CT	163 (38.3%)	181 (38.5%)	1.101 (0.836∼1.451)	1.294 (0.864∼1.939)
TT	17 (4.0%)	41 (8.7%)	2.392 (1.323∼4.325)*	2.541 (1.071∼6.027)*
CT+TT	180 (42.3%)	222 (47.2%)	1.223 (0.939∼1.593)	1.422 (0.967∼2.092)
rs2046463
AA	246 (57.7%)	248 (52.8%)	1.00	1.00
AG	163 (38.3%)	181 (38.5%)	1.101 (0.836∼1.451)	1.294 (0.864∼1.939)
GG	17 (4.0%)	41 (8.7%)	2.392 (1.323∼4.325)*	2.541 (1.071∼6.027)*
AG+GG	180 (42.3%)	222 (47.2%)	1.223 (0.939∼1.593)	1.422 (0.967∼2.092)

Odds ratios and with their 95% confidence intervals were estimated by logistic regression models. Adjusted odds ratios with their 95% confidence intervals were estimated by multiple logistic regression models after controlling for age, betel-nut chewing, tobacco use, and alcohol consumption. * Statistically significant, p<0.05.