Table 3. Adjusted odds ratios (AORs) and 95% confidence intervals (CIs) of associations of VEGF-C genotypic frequencies and betel-nut chewing among 611 smokers with male oral cancer.
| Variable | Controls(n = 202) (%) | Patients(n = 409) (%) | OR (95% CI) | AOR (95% CI) |
| rs3775194 | ||||
| a GG genotype without betel-nut chewing | 90 (44.6%) | 41 (10.1%) | 1.00 | 1.00 |
| b GC or CC genotype or betel-nut chewing | 86 (42.6%) | 284 (69.4%) | 7.249 (4.663∼11.268) | 11.688 (6.534∼20.907) |
| c GC or CC genotype with betel-nut chewing | 26 (12.9%) | 84 (20.5%) | 7.092 (3.993∼12.595) | 14.501 (6.899∼30.479) |
| rs11947611 | ||||
| a AA genotype without betel-nut chewing | 50 (24.8%) | 32 (7.8%) | 1.00 | 1.00 |
| b AG or GG genotype or betel-nut chewing | 119 (58.9%) | 156 (38.2%) | 2.048 (1.238∼3.390) | 2.827 (1.491∼5.360) |
| c AG or GG genotype with betel-nut chewing | 33 (16.3%) | 221 (54.0%) | 10.464 (5.888∼18.597) | 19.030 (9.239∼39.197) |
| rs1485766 | ||||
| a CC genotype without betel-nut chewing | 44 (21.8%) | 28 (6.8%) | 1.00 | 1.00 |
| b CA or AA genotype or betel-nut chewing | 109 (54.0%) | 140 (34.2%) | 2.018 (1.181∼3.449) | 2.670 (1.302∼5.473) |
| c CA or AA genotype with betel-nut chewing | 49 (24.3%) | 241 (59.0%) | 7.729 (4.394∼13.594) | 15.676 (7.413∼33.150) |
| rs7664413 | ||||
| a CC genotype without betel-nut chewing | 80 (39.6%) | 34 (8.3%) | 1.00 | 1.00 |
| b CT or TT genotype or betel-nut chewing | 96 (47.5%) | 210 (51.3%) | 5.147 (3.222∼8.221) | 7.241 (3.981∼13.172) |
| c CT or TT genotype with betel-nut chewing | 26 (12.9%) | 165 (40.4%) | 14.932 (8.392∼26.569) | 24.220 (11.601∼50.566) |
Odds ratios with their 95% confidence intervals were estimated by logistic regression models.
Adjusted odds ratios with their 95% confidence intervals were estimated by multiple logistic regression models after controlling for age and alcohol consumption.
a
Individuals with the wild-type genotype who do not chew betel nut.
b
Individuals with either at least one mutated genotype or who chew betel nut.
c
Individuals with both at least one mutated genotype and who chew betel nut.