Table 4. FCN2 genotype frequencies (%) in Chagas patients and controls.

FCN2N	Controls305	Patients243	Indeterminate88	Symptomatic152	Cardiac96	Digestive23	Associated33
AAAA/AAAA	10 (3.3)	6 (2.5)	3 (3.4)	3 (2.0)	2 (2.1)	0	1 (3.0)
AAAA/AGAA	6 (2.0)	7 (2.9)	3 (3.4)	4 (2.6)	3 (3.1)	0	1 (3.0)
AAAA/AGGA	22 (7.2)	14 (5.8)	7 (8.0)	6 (4.0)	3 (3.1)	2 (8.7)	1 (3.0)
AAAA/GGAA	20 (14.8)*	36 (14.8)	11 (12.5)	25 (16.4)	15 (15.6)	4 (17.4)	6 (18.2)
AAAA/GGAS	7 (5.2)*	18 (7.4)	7 (8.0)	10 (6.6)	7 (7.3)	1 (4.3)	2 (6.1)
AAA/GGA	57 (18.7)	54 (22.2)	18 (20.5)	35 (23.0)	22 (22.9)	5 (21.7)	8 (24.2)
AGAA/AGAA	0	1 (0.4)	1 (1.1)	0	0	0	0
AGAA/AGGA	9 (3.0)	4 (1.6)	3 (3.4)	1 (0.7)	1 (1.0)	0	0
AGAA/GGAA	7 (5.2)*	9 (3.7)	1 (1.1)	7 (4.6)	5 (5.2)	2 (8.7)	0
AGAA/GGAS	2 (1.5)*	2 (0.8)	2 (2.3)	0	0	0	0
AGA/GGA	27 (8.9)	11 (4.5)	3 (3.4)	7 (4.6)	5 (5.2)	2 (8.7)	0
AGGA/AGGA	18 (5.9)	12 (4.9)	2 (2.3)	10 (6.6)	7 (7.3)	2 (8.7)	1 (3.0)
AGGA/GGAA	31 (23.0)*	36 (14.8)	15 (17.0)	21 (13.8)	12 (12.5)	3 (13.0)	6 (18.2)
AGGA/GGAS	3 (2.2) *	22 (9.1)	7 (8.0)	15 (9.9)	7 (7.3)	2 (8.7)	6 (18.2)
AGG/GGA	79 (25.9)	58 (23.9)	22 (25.0)	36 (23.7)	19 (19.8)	5 (21.7)	12 (36.4)
GGAA/GGAA	18 (13.3)*	47 (19.3)	19 (21.6)	28 (18.4)	20 (20.8)	3 (13.0)	5 (15.2)
GGAA/GGAS	17 (12.6)*	26 (10.7)	6 (6.8)	20 (13.2)	14 (14.6)	4 (17.4)	2 (6.1)
GGAS/GGAS	0 *	3 (1.2)	1 (1.1)	2 (1.3)	0	0	2 (6.1)
GGA/GGA	77 (25.2)	76 (31.3)	26 (29.5)	50 (32.9)	34 (35.4)	7 (30.4)	9 (27.3)

In bold: genotypes with −4 A/G heterozygosity, whose summed frequencies differ between cardiac patients and controls. Gray-shadowed: genotypes AGGA/GGAS and GGAS/GGAS (homozygote for A258S), whose summed frequencies differ between cardiodigestive patients and indeterminate patients or controls (see text).

^* A258S was investigated by sequencing in a subset of 135 controls. n number of individuals.