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. 2013 Apr 4;8(4):e60411. doi: 10.1371/journal.pone.0060411

Figure 4. Bioluminescence images of streptozotocin (STZ) -treated Ins1-luc BAC transgenic mice.

Figure 4

(A) Representative bioluminescence images of Ins1-luc BAC transgenic male mice before and after treatment with vehicle control or STZ. Circles indicate regions of interest. (B) Quantification of signal intensity in the vehicle control group (n = 5) and the STZ group (n = 5) at 0, 5, and 15 days after the injection. *P = 0.025. (C) Immunohistochemistry for anti-insulin antibody in the islets of Ins1-luc BAC transgenic mice treated with vehicle control or STZ. Scale bars: 50 µm. (D) β-cell mass in the vehicle control group (n = 3) and in the STZ-treated group (n = 4).