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. 2013 Feb 28;288(14):9790–9800. doi: 10.1074/jbc.M112.438804

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Proposed model of the ORG27569-induced β-arrestin 1-mediated ERK1/2 signaling. ORG27569 binding to CB1 promotes β-arrestin 1 recruitment which in turn recruits Src, MEK1/2, and ERK1/2 kinases to form a signaling complex.