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. 2013 Feb 20;288(14):9957–9970. doi: 10.1074/jbc.M113.458372

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Macrophage stimulation with the PPARα agonist CP900691 (CP), the PPARγ agonist rosiglitazone (Rosi), or the PPARδ agonist GW 0742 (GW) does not induce ACSL1 expression. Treatment with the PPARα and PPARδ agonists partially attenuated LPS-mediated increases in ACSL1. Similar findings were observed at the mRNA (A) and protein (B) levels. Effective PPAR activation was verified by increased expression of the known PPAR target genes Cd36 (C) and Cpt1a (D). *, p < 0.05; **, p < 0.01; ***, p < 0.001 versus vehicle control. #, p < 0.05; ###, p < 0.001 versus LPS-stimulated samples. Error bars, S.E.