Table I. Antibodies toward Lewis carbohydrate antigens.
Antibodies to Lewis epitopes with clone name, isotype, and reference regarding its original production (if known) are shown. Specificity and cross-reactivity of the antibodies were extracted from literature and CFG Glycan Array screening results. The Lewis epitopes are abbreviated Le, with the superscript indicating specific identity (A, B, X, and Y); an S preceding the epitope indicates sialylation, and Di indicates a di-Lewis structure. BG-H1 and BG-H2 indicate blood group H1 and H2 glycan antigens. NA, not available.
| Epitope | Clone | Isotype | Ref. | Specificity and cross-reactivity |
|---|---|---|---|---|
| Lea | T174 | IgG1 | Sakamoto et al., 1986 (106) | Lea = SLea |
| 7LE | IgG1 | Daher et al., 1987 (107) | Lea, Lex | |
| Leb | T218 | IgM | Sakamoto et al., 1986 (106) | Leb > Lea > BG-H1 |
| 2–25LE | IgG1 | Bara et al., 1986 (108) | Leb ≫ Lea | |
| Lex | P12 | IgM | Richman, 1987 (109) | Lex = DiLex |
| 28 | IgM | Hogg et al., 1984 (110) | DiLex > Lex | |
| SH1 | IgG3 | Singhal et al., 1990 (111) | DiLex > Lex | |
| Ley | AH-6 | IgM | Abe et al., 1983 (112) | Ley |
| F3 | IgM | Lloyd et al., 1983 (113) | Ley > BG-H2 > Lex | |
| BR55 | IgG2a | NA | Ley ≫ DiLex > Lex |