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. 2013 Apr 4;92(4):547–557. doi: 10.1016/j.ajhg.2013.03.003

Figure 1.

Figure 1

Frameworks of Conventional and Genetically Enriched Prevention Trials

(A) Conventional prevention trial not utilizing genetic information.

(B) Standard genetic enrichment trial following up only individuals at high genetic risk after genetic screening.

(C) Biobank-based enrichment trial where DNA information is available a priori and used for inviting individuals at the beginning of trial.