Table 2.
Disease Liability Explained by Currently Known Risk Variants
| Genetic Risk Threshold |
Fold Enrichment from Baseline Disease Prevalence (in Parentheses)a |
|||
|---|---|---|---|---|
| T2D (3.0%) | AMD (11.8%) | T1D (0.54%) | MI (4.0%) | |
| Top 50% genetic risk | 1.32 | 1.65 | 1.84 | 1.23 |
| Top 20% genetic risk | 1.67 | 2.63 | 3.42 | 1.43 |
| Top 10% genetic risk | 1.92 | 3.36 | 4.96 | 1.57 |
| Top 5% genetic risk | 2.17 | 4.07 | 6.82 | 1.69 |
| Top 2% genetic risk | 2.50 | 4.63 | 9.78 | 1.83 |
| Top 1% genetic risk | 2.74 | 4.81 | 12.42 | 1.94 |
a
The ratio of prevalence in the individuals with top genetic risk to the baseline prevalence in Table 1.