Table 1.

CNVs Identified from BAC and Fosmid Clones

Individual	Population	CNV Type	IGHV Genes Included in CNVa	GRCh37 Outer-Start (Breakpoint)b	GRCh37 Outer-End (Breakpoint)b	Event Size (∼kbp)	Accessions/Clones
CH17	nd	Insertion	V1-69D, V1-f, V3-h, V2-70D (gain)	107174927	107174941	46.6	AC245023, AC245094
CH17	nd	Complex event	V4-30-2 (gain) V4-31 (loss)	106804332	106810878	6.5c/48.8d	AC245166
CH17	nd	Complex event	V5-a, V3-64D (gain) V3-9, V1-8 (loss)	106531320	106569343	38c/37.7e	AC245085, AC247036
CH17	nd	Insertion	V7-4-1 (gain)	106483362	106484225	9.5	AC244226, AC245085, AC247036
NA12156	CEPH	Deletion	V4-39, V3-38 (loss)	106866357	106899042	32.7	AC244497
NA15510 and NA19240	nd and Yoruba	Insertion	V1-c, V3-d, V3-43D, V4-b (gain)	106877146	106877535	61.1	AC241995, AC234225; AC233755, KC162926f
NA18555 (haplotype A)	Han Chinese	Complex event	V3-30-5, V4-30-4, V3-30-3, V4-30-2 (gain)	106804332	106804333	49.2	KC162924, AC231260, AC244456, KC162925
NA18555 (haplotype B)	Han Chinese	Deletion	V4-31, V3-30 (loss)	106786254	106811213	24.9c/73.9d	AC244464
NA18507	Yoruban	Complex eventg	V4-30-4, V3-30-3 (gain) V3-30 (loss)	106784242	nd	25.2	AC244411
NA18502	Yoruban	Complex eventg	V3-30-5 (gain) V3-33, V4-31 (loss)	nd	106820685	24.7	AC245243
NA18956 and NA12156	Japanese and CEPH	Duplication	V3-23D (gain)	106716650	106727861	10.8	AC244473, AC206018; AC244492
NA19240 and NA12878	Yoruban and CEPH	Insertion	V7-4-1 (gain)	106483362	106484225	9.5	AC241513; AC245090

nd, not defined;

^aGenes either lost or gained in the context of GRCh37 as part of CNV-containing haplotypes are noted.

^bCoordinates delineate regions in which event breakpoints are predicted to have occurred.

^cEvent size with respect to GRCh37.

^dEvent size with respect to NA18555 haplotype A (see Figure 4).

^eEvent size with respect to CH17.

^fClones from these two individuals were used to build a composite haplotype.

^gPartially characterized.