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. 2013 Apr 5;7:27. doi: 10.3389/fncom.2013.00027

Figure 4.

Figure 4

The impaired synaptic plasticity in CA3-CA1 pathway paralleling with the decreased directional CFC index between CA3 theta rhythm and CA1 gamma rhythm in 2VO group. (A) STP and LTP were elicited by the tetanic stimulation indicated by the arrow. The fEPSPs slope was normalized to baseline. (B) Magnitudes of STP and LTP, determined as responses between 0 and 10 min and between 50 and 60 min after tetanic stimulation, were significantly smaller in 2VO rats. (C) CFC analysis measured by MI method between CA3 theta and CA1 gamma rhythms in the two groups. Considerably decreased MI values could be seen in 2VO group. (D) Statistical results of CA3 gamma power spectra in one CA1 theta cycle between the two groups. A difference that was no statistically significant could be seen. (E) Directional CFC index from CA3 theta rhythm to CA1 gamma rhythm measured by CF-CMI was significantly reduced in 2VO rats. **p < 0.01 and ***p < 0.001 comparison between Con and 2VO groups.