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Inhibition of NTCP by irbesartan. Taurocholate uptake into NTCP-HEK293 cells was reduced in the presence of irbesartan in a concentration-dependent fashion. Inhibition studies were conducted using seven concentrations of irbesartan (0–200 μM). Closed circles indicate observed data points, while the solid line indicates model fit. Observed Ki of irbesartan was 11.9(±0.7) μM.
