Table 4.
Comparison of 72 drugs in terms of NTCP and ASBT inhibition. For each NTCP and ASBT, estimated Ki was derived from a single inhibitor concentration. Compounds are listed in order of estimated Ki for NTCP.
| Compounds | Est Ki for NTCP (μM) | Est Ki for ASBT (μM) |
|---|---|---|
| Cyclosporine A | 10.3±1.1 | 41.0±7.4 |
| Irbesartan | 12.0±1.6 | 131±34 |
| Ritonavir | 25.1±1.6 | 47.3±9.7 |
| Bendroflumethiazide | 26.2±1.0 | 168±10 |
| Doxazosin | 41.2±7.1 | 20.9±7.3 |
| Ezetimibe | 53.8±3.3 | 4.61±0.88 |
| Simvastatin | 57.3±11 | 99.1±19 |
| Nitrendipine | 72.3±5.2 | 31.7±6.5 |
| Itraconazole | 77.1±38 | 57.0±25 |
| Nimodipine | 86.5±5.4 | 30.9±1.7 |
| Reserpine | 89.1±65 | 21.6±2.9 |
| Ketoconazole | 98.8±12 | 61.9±27 |
| Isradipine | 99.5±14 | 17.9±2.3 |
| Rosuvastatin | 100±12 | 164±34 |
| Nefazodone | 100±8 | 30.8±3.6 |
| Losartan | 105±9 | 139±58 |
| Nateglinide | 111±7 | 77.0±16 |
| Sulconazole | 112±115 | 29.4±0.6 |
| Indomethacin | 141±14 | 31.3±7.7 |
| Nifedipine | 144±43 | 89.9±34 |
| Candesartan | 145±44 | 67.6±30 |
| Cerivastatin | 150±52 | 220±100 |
| Tioconazole | 177±66 | 11.9±2.7 |
| Lovastatin | 202±32 | 21.7±2.1 |
| Fenofibrate | 211±60 | 121±33 |
| Naproxen | 217±69 | 136±13 |
| Sulfanilamide | 250±50 | 194±24 |
| Methylprednisolone | 255±53 | 3000 |
| Budesonide | 264±94 | 62.6±15 |
| Prochlorperazine | 280±37 | 27.4±4.6 |
| Furosemide | 304±132 | 3000 |
| Nicardipine | 309±144 | 142±3 |
| Raloxifene HCl | 321±139 | 65.8±9.2 |
| Cimetidine | 332±73 | 208±51 |
| Prednisolone | 335±177 | 89.2±32 |
| Chloroquine | 336±101 | 3000 |
| Ketoprofen | 361±178 | 480±609 |
| Metronidazole | 369±83 | 223±90 |
| Procainamide HCl | 384±185 | 3000 |
| Famotidine | 387±130 | 2275±978 |
| Propafenone HCl | 402±116 | 50.3±18 |
| Triamterene | 411±139 | 110±3 |
| Econazole | 416±624 | 18.5±3.9 |
| Olmesartan | 422±204 | 1049±422 |
| Probenecid | 435±114 | 425±155 |
| Diltiazem | 460±232 | 237±21 |
| Ethosuximide | 513±169 | 313±53 |
| Miconazole | 601±300 | 61.3±16 |
| Imatinib | 673±130 | 177±32 |
| Chlorpromazine | 767±268 | 50.7±5.9 |
| Abacavir | 1291±4144 | 1460±5960 |
| Quinine | 1491±581 | 239±117 |
| Sulfinpyrazone | 1664±2871 | 529±600 |
| Nafcillin | 2006±5836 | 3000 |
| Acarbose | 3000 | 318±169 |
| Aztreonam | 3000 | 1419±5313 |
| Bortezomib | 3000 | 811±243 |
| Cefaclor | 3000 | 1886±257 |
| Daunorubicin | 3000 | 3000 |
| Dibucaine | 3000 | 85.8±2.3 |
| Eletriptan | 3000 | 137±48 |
| Enalapril | 3000 | 162±82 |
| Eprosartan | 3000 | 246±119 |
| Formoterol | 3000 | 175±96 |
| Omeprazole | 3000 | 103±23 |
| Oseltamivir | 3000 | 1022±49 |
| Oxiconazole | 3000 | 94.7±38 |
| Ropinirole | 3000 | 30.3±11 |
| Thiothixene | 3000 | 3000 |
| Valsartan | 3000 | 1265±7010 |
| Warfarin | 3000 | 97.4±26 |
| Yohimbine | 3000 | 377±442 |