Figure 4. Therapeutic efficacy of IRT-P-HA-NPs.

(a) Tumor growth and (b) survival rate of HT29 human colon cancer xenografts treated with saline, free IRT and IRT-P-HA-NPs at a dose of 10 mg IRT/kg. (c) Representative histological images of liver and tumor slices stained using hematoxylin and eosin. The organs were excised at 30 days after the start of administration. Arrows indicate necrosis in tissues. Asterisk symbols (*) denote statistically significant differences (*: p<0.05) calculated using the one-way ANOVA test. Error bars in a and b represent standard deviations (n=8).