Figure 5. Therapeutic monitoring of orthotopic colon tumors.
(a) Diagram of the general procedure (b) Representative colon images of AOM/DSS-induced orthotopic colon cancer models that were pre-treated or treated with saline, IRT or IRT-P-HA-NPs. Images acquired at 6 h after intravenous injection of Cy5.5-P-HA-NPs. White and red arrows indicate adenomas and adenocarcinomas, respectively. Quantitative results of (c) histological polyp examination and (d) tumor weight. Asterisk symbols (*) denote the statistically significant differences (*: p<0.05) calculated using the one-way ANOVA test. Error bars in a and b represent the standard deviations (n=6).