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. Author manuscript; available in PMC: 2013 Apr 5.
Published in final edited form as: J Cell Physiol. 2009 Oct;221(1):31–39. doi: 10.1002/jcp.21809

Fig. 5.

Fig. 5

Cysteinyl leukotrienes are negative regulators of chondrocyte proliferation. Col 2a1 and SOX9 mRNA expression analyzed by qPCR of fracture callous tissue at days 7, 10, 14, and 21. Peak levels of chondrocyte markers seen in all groups at day 7. These markers showed prolonged expression in treatment animals compared with controls. In control animals, expression drops markedly after day 10. In the montelukast sodium group, Col 2a1 expression is elevated at day 14 (P < 0.05) and in the zileuton group both SOX9 and Col 2a1 are elevated at day 10 (P < 0.05).