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. 2012 Oct 24;32(43):15169–15180. doi: 10.1523/JNEUROSCI.2466-12.2012

Figure 1.

Figure 1.

Increased expression of Erbin and ErbB receptors in injured nerves. A, Western blots showing increased expression of Erbin, ErbB2, and ErbB3 in distal segments of injured nerves. Distal segments at indicated days after injury were homogenized and subjected to Western blotting with indicated antibodies. B, Quantitative data of A. n = 3. **p < 0.01; *p < 0.05, compared with uninjured control. ErbB2 levels were increased in distal segments of injured sciatic nerves to 6.7 ± 1.67- and 16.3 ± 1.02-fold and ErbB3 levels to 1.8 ± 0.07- and 1.4 ± 0.08-fold (n = 3; p < 0.01) on days 5 and 20 after injury, respectively, whereas Erbin levels were increased to 4.7 ± 0.63-, 4.6 ± 0.86-, and 5.4 ± 1.30-fold (n = 3; p < 0.01) on days 3, 5, and 20, respectively. C, Erbin expression was increased in regenerated SCs. Longitudinal sections of injured distal segments on day 20 were costained with anti-Erbin antibody and DAPI. White arrows indicate Erbin staining; white arrowheads indicate hollow space between Erbin-stained myelin; yellow arrows indicate nuclei (elongated in proximal regions but round in distal segments). CTL, Control.