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Binding of K48-linked diubiquitin to the USP2 catalytic core requires an open diubiquitin conformation. The X-ray cocrystal structure of USP2 (grey) and ubiquitin (cyan) (30) are overlaid with the X-ray structure of a closed (A) or open (B) K48-linked diubiquitin (red) (16, 17). Due to steric constraints USP2 requires an open K48-linked diubiquitin conformation for binding to USP2.
