Figure 3.

Parameterization of the hyperpolarization effects of propofol and ketamine. (A) Shift of the α peak frequency, average over all 1,627 sets estimated as described below Eq. 11. (B) Likewise, but averaged over the 10 sets shown in Figure 2, which were selected for having large up (Δf > 1.6 Hz) and down (Δf < −0.8 Hz) shifts of α peak frequency, as well as a lack of shift for some large hyperpolarizations (|Δf(−3.7 mV, ≤4.3 mV)| < 0.4 Hz). (C) Blue contours indicate areas where 4, 7, or 10 sets have the required down-shift. A blue arrow points to the midpoint of this area, and drug effect parameters for Eq. 12 and Eq. 13 derived from this are listed in blue text. Likewise, parameters are derived for up-shift in red and a lack of shift in green. (D) These are the same results as in (B), but now plotted against normalized propofol P and ketamine K concentrations using the drug effect parameters found in (C).