Skip to main content
. Author manuscript; available in PMC: 2013 Apr 5.
Published in final edited form as: Cancer Res. 2008 Nov 15;68(22):9323–9330. doi: 10.1158/0008-5472.CAN-08-2873

Figure 4. Bortezomib induces apoptotic cell death in hypoxic DLD1 but not in HeLa cells.

Figure 4

(A) DLD1 cells were exposed to normoxic or hypoxic conditions for 12h before treatment with DMSO or bortezomib for 24h. Immunoblotting was performed using antibodies specific for cleaved PARP and β-actin (loading control). (B) HeLa cells were exposed to normoxic or hypoxic conditions for 12h before treatment with DMSO or bortezomib for 24h. Staurosporine (STS; 1μM, 4hr) was used as a control. Immunoblotting was performed using antibodies specific for cleaved caspase-3, cleaved PARP and β-actin (loading control).