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Fsp27/CIDEC is regulated by SIRT1 activity. A: Fsp27 mRNA levels in liver of wild-type (WT) and Sirt1-LKO mice fasted for 15 h. Data are the mean ± SEM (n = 5–6 mice). **P < 0.01 relative to WT. B: CIDEC mRNA levels in HepG2 cells treated with an siRNA control or siRNA of SIRT1. Results are means of ± SEM (n = 4 independent experiments). *P < 0.05 relative to control. C: Schematic model of the Fsp27/CIDEC regulatory pathway under early fasting.
