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Role of different ceramide generation pathways in doxorubicin-induced inhibition of cell survival. MCF7 cells were pretreated with or without fumonisin B1 (FB1) (A), myriosin (MYR) (B), desipramine (DES) (C), or GW4869 (GW) (D) for 1 h followed by treatment with 1 µM doxorubicin (DOX) or DMSO vehicle control for 48 h and SRB assay for survival as described in Materials and Methods. **P < 0.01.
