Table 2.
Functional gene ontology annotation using DAVID
| Gene name | KEGG pathway |
|---|---|
| ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c |
gga00190:Oxidative phosphorylation, gga04142:Lysosome |
| F-box protein 4 |
gga04120:Ubiquitin mediated proteolysis |
| cadherin 1, type 1, E-cadherin (epithelial) |
gga04514:Cell adhesion molecules (CAMs), gga04520:Adherens junction |
| erbb2 interacting protein |
gga04621:NOD-like receptor signaling pathway |
| etoposide induced 2.4 mRNA |
gga04115:p53 signaling pathway |
| interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) |
gga04060:Cytokine-cytokine receptor interaction, gga04620:Toll-like receptor signaling pathway, gga04622:RIG-I-like receptor signaling pathway, gga04630:Jak-STAT signaling pathway |
| jun oncogene |
gga04010:MAPK signaling pathway, gga04012:ErbB signaling pathway, gga04310:Wnt signaling pathway, gga04510:Focal adhesion, gga04620:Toll-like receptor signaling pathway, gga04912:GnRH signaling pathway |
| mago-nashi homolog, proliferation-associated (Drosophila) |
gga03040:Spliceosome |
| phosphomannomutase 2 |
gga00051:Fructose and mannose metabolism, gga00520:Amino sugar and nucleotide sugar metabolism |
| proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) |
gga03050:Proteasome |
| ribosomal protein L35a |
gga03010:Ribosome |
| secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) |
gga04510:Focal adhesion, gga04512:ECM-receptor interaction, gga04620:Toll-like receptor signaling pathway |
| thioredoxin reductase 1 | gga00240:Pyrimidine metabolism |
The gene list containing the 61 differentially expressed genes in duck spleen common to all three LPAIV infections at 3 d.p.i. was entered into the DAVID functional annotation software. The following genes and their cognate KEGG pathways are enriched (up- and/or down-regulated) in our dataset.