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. 2013 Apr 5;8(4):e60803. doi: 10.1371/journal.pone.0060803

Figure 5. Levels of brain DA and its metabolites are irrelevant to the dietary tyrosine supplementation in Spr −/− mice.

Figure 5

(A), (B), and (C) Spr +/+ or Spr −/− mice were fed a normal (ND) or the tyrosine diet (+Tyr). Mice were analyzed for brain levels of DA (A), DOPAC (B), and HVA (C) in their caudate putamen (n ≥3). Values are means ± SD, ** P<0.01, *** P<0.001, compared with respective values in Spr +/+ mice. (D) The brain levels of TH proteins in experimental mice were monitored by Western blot analysis. Spr +/+ or Spr −/− mice were fed a normal diet or treated with the dietary tyrosine, L-DOPA, or leucine therapy for 10 days as described in Materials and Methods.