Figure 1.

Motor coordination evaluated with the rotarod test in Spraque-Dawley rats. Animals received stereotaxically either saline (n = 8) or a collagenase solution (n = 7) in the ventroposterolateral nucleus of the thalamus. No significant difference was seen between sham and collagenase groups at baseline and at different post surgical time points up to 22 days (F_1,13 = 0.18, ns). Only the IP administration of 25 mg/kg of ketamine caused a significant impairment (p < 0.05) in motor coordination seen in both groups.