Figure 3.
Evaluation of mechanical allodynia using Von Frey filaments. No significant difference was seen for both hind limbs at baseline values between both saline and collagenase groups. As early as the second post-surgical day, a significant decrease in the mechanical threshold in both hind limbs was noted for the collagenase group when compared to sham animals in the right (F1,24.5 = 130.4, p < 0.0001) and left (F1,28.1 = 207.8, p < 0.0001) hind paws. Only the 25 mg/kg of ketamine dose reduced mechanical allodynia in the contralateral (p < 0.0001) and ipsilateral (p < 0.01) hind paws.