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. 2013 Feb 7;14:19. doi: 10.1186/1471-2202-14-19

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Copyright © 2013 Vilela et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Brain histopathological changes after intracerebral inoculation of 10⁴PFU of HSV-1 in WT and CCR5^-/-mice, at 1 dpi. H&E-stained sections of meninges and cerebral cortex. Meninges of non-infected WT mouse (A) and CCR5^-/- animal (D) with normal brain tissue (n = 3 in each group); WT infected animal showing infiltration of immune cells in the meninges (B-C); Intense meningitis characterized by infiltration of polimorphonuclear and mononuclear in CCR5^-/- mouse (E-F). A-B: ×200; D-E: ×100; C-F: ×400.