Table 1. Subject population, psychological testing, and physiologic variables measured during PET studies of propofol-sedated subjects.
| Healthy volunteers | Fragile X subjects | |
|---|---|---|
| Age (years) | 22.5±0.5 | 21.6±0.6 |
| Body weight (kg) | 89±4 | 85±4 |
| WAIS full scalea | 130±5 | 53±1** |
| WAIS verbala | 134±4 | 58±1** |
| WAIS performancea | 118±5 | 55±1** |
| Arterial plasma leucine (μmol/L) | 126±4 | 119±4 |
| ∑[LNAA]i/kmi | 12.4±0.3 | 11.3±0.4 |
| Arterial plasma glucose concentration (mmol/L) | 5.9±0.1 | 5.6±0.2 |
| Hematocrit (%) | 47±1 | 49±1* |
| BiSpectral index (BIS) | 33±2 | 29±2 |
| MABP (mm Hg) | 69±2 | 70±2 |
| Heart rate (beats/min) | 76±3 | 74±3 |
| Arterial blood pH | 7.31±0.01 | 7.28±0.01 |
| Arterial pCO2 (mm Hg)b | 52±2 | 56±3 |
| Arterial pO2 (mm Hg)c | 142±9 | 194±24 |
| Arterial plasma propofol concentration (μmol/L) | 36±4 | 51±7 |
LNAA, large neutral amino acids; MABP, mean arterial blood pressure; PET, positron emission tomography; WAIS, Wechsler Adult Intelligence Scale.
Physiologic variables are time weighted.
Statistically significantly different from healthy volunteers, two-tailed t-tests; *P⩽0.05; **P<0.0001.
Values are means±s.e.m. for 12 healthy volunteers and 15 Fragile X subjects, except where indicated.
a
10 healthy volunteers and 13 Fragile X subjects.
b
10 healthy volunteers and 15 Fragile X subjects.
c
11 healthy volunteers and 15 Fragile X subjects.