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. 2013 Feb 6;33(4):583–592. doi: 10.1038/jcbfm.2012.209

Figure 6.

Figure 6

Therapeutic window of nanoparticles treatment. Mice were subjected to 1 hour of ischemia followed by 48 hours of reperfusion. Animals were administered PBCA/SOD nanoparticles at 1, 2, 4, 8, or 24 hours of reperfusion and then killed at 48 hours. Control, uninjected animals. Brains were subject to triphenyltetrazolium chloride (TTC) staining for infarct volumes. N=10 per time point. *P<0.01; **P<0.005; ***P<0.001; NS, not significant. PBCA, polybutylcyanoacrylate; SOD, superoxide dismutase.