Figure 1. Melanoma cell lines can be sensitized to birinapant by co-treatment with TNF-α.

Seventeen human melanoma cell lines representing major mutational subgroups of cutaneous melanoma were treated with birinapant at concentrations up to 1uM, alone (grey bars) or in combination with TNF-α 1ng/ml (black bars). Values on the y-axis represent IC50 values as assessed by the MTS proliferation assay at 72h. Data labels indicate IC50 values from mean value of biological triplicates.