Table 1.
Parameters measured in the ex vivo thrombosis system. Data indicate mean ± one standard deviation. Rt-PA and Definity® concentrations calculated based on the infusion pump flow rate and average flow rate through the artery.
| Plasma Alone
|
rt-PA
|
rt-PA, Definity + US
|
||||
|---|---|---|---|---|---|---|
| Retracted Clots
|
Unretracted Clots
|
Retracted Clots
|
Unretracted Clots
|
Retracted Clots
|
Unretracted Clots
|
|
| Temperature (C) | 37.53 (0.27) | 36.9 (0.37) | 37.09 (0.37) | 37.14 (0.40) | 37.23 (0.15) | 37.32 (0.40) |
| Fluid Pressure (mmHg) | 99.1 (4.0) | 93.1 (6.2) | 95.5 (2.5) | 100.1 (4.8) | 98.1 (1.5) | 101.0 (4.0) |
| Flow Rate (mL/min) | 1.54 (0.03) | 1.78 (0.10) | 1.40 (0.13) | 1.39 (0.04) | 1.46 (0.04) | 1.45 (0.08) |
| [rt-PA]calc (mcg/min) | - | - | 3.37 (0.24) | 3.39 (0.08) | 3.24 (0.08) | 3.26 (0.15) |
| [Definity]calc (mcL/min) | - | - | - | - | 0.29 (0.01) | 0.29 (0.01) |