Table 1.
CD20loCD19+ B cells from B-CLL patients suppress T cells
Patients | Compared to ND | Rituximab | ||
---|---|---|---|---|
CD20 decrease * | Suppression | 4-1BBL | ||
1 | + | +++ | Low | + |
− | − | Low | − | |
2 | − | − | ND | − |
− | − | ND | − | |
3 | + | +++ | Low | + |
4 | + | ++ | Low | − |
5 | + | ++ | Low | − |
6 | + | ++ | Equal | + |
7 | + | + | ND | + |
8 | + | + | High | − |
9 | − | − | Equal | − |
10 | − | − | High | − |
11 | − | − | Equal | − |
12 | − | + | Low | + |
13 | + | ++ | low | + |
CD19+ B cells from B-CLL patients were phenotyped for CD20 and 4-1BBL expression and tested for T cell suppression
+ corresponds to > 40% decrease compared to ND