TABLE 3.
ASSOCIATION OF BASELINE CHARACTERISTICS WITH PRE-BOS ASPERGILLUS COLONIZATION ACCORDING TO CONIDIA SIZE – JOINED COHORT
| Small Conidia Asp Species |
Large Conidia Asp Species |
|||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Univariable models | ||||||
| Female Gender | 1.09 | 0.83–1.43 | 0.55 | 1.04 | 0.76–1.42 | 0.81 |
| Age ≥ 65 | 1.64 | 1.17–2.25 | 0.004 | 0.98 | 0.63–1.47 | 0.94 |
| Race | ||||||
| Caucasian | 1.30 | 0.83–2.16 | 0.26 | 0.72 | 0.48–1.16 | 0.17 |
| African American | 0.66 | 0.36–1.11 | 0.12 | 1.36 | 0.81–2.17 | 0.24 |
| Native Disease | ||||||
| Restrictive | 1.02 | 0.77–1.34 | 0.91 | 0.98 | 0.71–1.35 | 0.92 |
| Obstructive | 1.01 | 0.76–1.33 | 0.96 | 1.07 | 0.78–1.47 | 0.67 |
| CF/bronchiectasis | 0.92 | 0.61–1.35 | 0.69 | 0.92 | 0.57–1.42 | 0.73 |
| Vascular | 1.23 | 0.56–2.33 | 0.58 | 0.99 | 0.35–2.17 | 0.98 |
| Bilateral Transplant | 0.87 | 0.63–1.21 | 0.39 | 2.16 | 1.36–3.65 | 0.001 |
| ATG Induction | 0.89 | 0.67–1.16 | 0.39 | 0.96 | 0.70–1.31 | 0.80 |
| CMV Mismatch (D+/R−) | 0.94 | 0.66–1.30 | 0.69 | 0.89 | 0.59–1.30 | 0.57 |
| Center = DUMC | 0.91 | 0.68–1.21 | 0.50 | 1.86 | 1.30–2.72 | 0.001 |
| Prophylaxis Era (ABLC) | 1.34 | 0.95–1.96 | 0.10 | 1.21 | 0.83–1.86 | 0.33 |
| Mulivariable models | ||||||
| Age ≥ 65 | 1.58 | 1.12–2.19 | 0.01 | - | - | - |
| Prophylaxis Era (ABLC) | 1.25 | 0.88–1.83 | 0.22 | - | - | - |
| Center = DUMC | 0.98 | 0.73–1.31 | 0.85 | 1.61 | 1.11–2.38 | 0.01 |
| Bilateral Transplant | - | - | - | 1.79 | 1.10–3.08 | 0.02 |
Abbreviations: Asp: Aspergillus CF: cystic fibrosis. ATG: anti-thymocyte globulin. CMV: cytomegalovirus, DUMC: Duke University Medical Center.