TABLE 5.
COX MODELS FOR RISK OF MORTALITY
| UCLA Cohort |
DUMC Cohort |
Joined Cohort* |
||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Univariable Models | ||||||
| Female Gender | 0.80 (0.56–1.15) | 0.23 | 1.06 (0.80–1.39) | 0.70 | 0.95 (0.76–1.18) | 0.65 |
| Age ≥ 65 | 1.50 (1.01–2.23) | 0.04 | 1.27 (0.83–1.93) | 0.27 | 1.46 (1.1–1.93) | 0.009 |
| Diagnosis | ||||||
| Restrictive/other | Reference | Reference | Reference | |||
| Obstructive | 1.14 (0.80–1.63) | 0.47 | 0.86 (0.64–1.17) | 0.35 | 0.92 (0.73–1.16) | 0.50 |
| CF/bronchiectasis | 0.21 (0.05–0.87) | 0.03 | 0.88 (0.59–1.30) | 0.51 | 0.71 (0.50–1.02) | 0.06 |
| Single Lung Txp | 1.36 (0.95–1.93) | 0.09 | 1.63 (1.15–2.30) | 0.006 | 1.62 (1.28–2.05) | <0.001 |
| ATG Induction | 1.17 (0.8–1.70) | 0.42 | 1.06 (0.80–1.39) | 0.70 | 1.15 (0.93–1.43) | 0.20 |
| AR Ratio | 1.36 (0.95–1.93) | 0.13 | 1.77 (1.17–2.67) | 0.007 | 1.51 (1.13–2.02) | 0.006 |
| BOS | 5.07 (3.45–7.44) | <0.001 | 8.84 (6.50–12.1) | <0.001 | 7.21 (5.67–9.16) | <0.001 |
| CMV Pneumonitis | 1.10 (0.35–3.48( | 0.87 | 1.64 (1.23–2.19) | <0.001 | 1.36 (1.04–1.76) | 0.02 |
| Pseudomonas | 2.01 (1.40–2.88) | <0.001 | 1.63 (1.22–2.18) | 0.001 | 1.79 (1.43–2.24) | <0.001 |
| CARV | 2.04 (1.22–3.42) | 0.007 | 1.53 (1.06–2.21) | 0.02 | 1.64 (1.22–2.21) | 0.001 |
| Small conidia Asp sp | 1.79 (1.25–2.56) | 0.002 | 1.77 (1.33–2.35) | <0.001 | 1.81 (1.45–2.27) | <0.001 |
| Large conidia Asp sp | 1.29 (0.81–2.07) | 0.29 | 1.11 (0.82–1.51) | 0.51 | 1.11 (0.86–1.44) | 0.42 |
| Multivariable Model | ||||||
| Age ≥ 65 | 1.32 (0.84–2.06) | 0.23 | 1.08 (0.70–1.67) | 0.72 | 1.22 (0.91–1.64) | 0.19 |
| CF/bronchiectasis | 0.27 (0.07–1.11) | 0.07 | 1.17 (0.81–1.68) | 0.40 | 0.99 (0.70–1.39) | 0.93 |
| Single Lung Txp | 1.17 (0.78–1.77) | 0.45 | 1.13 (0.78–1.63) | 0.53 | 1.22 (0.93–1.58) | 0.15 |
| AR Ratio | 1.02 (0.65–1.58) | 0.94 | 0.93 (0.63–1.37) | 0.73 | 0.95 (0.72–1.26) | 0.72 |
| BOS | 4.24 (2.93–6.55) | <0.001 | 8.50 (6.16–11.7) | <0.001 | 6.49 (5.06–8.34) | <0.001 |
| CMV Pneumonitis | 1.09 (0.33–3.60) | 0.89 | 1.50 (1.11–2.02) | 0.009 | 1.49 (1.12–1.98) | 0.007 |
| Pseudomonas | 1.54 (1.05–2.28) | 0.03 | 1.68 (1.24–2.27) | <0.001 | 1.59 (1.26–2.02) | <0.001 |
| CARV | 1.93 (1.14–3.26) | 0.01 | 1.34 (0.92–1.94) | 0.13 | 1.55 (1.14–2.09) | 0.005 |
| Small conidia Asp sp | 1.24 (0.85–1.81) | 0.27 | 1.30 (0.96–1.75) | 0.09 | 1.30 (1.03–1.64) | 0.03 |
| Large conidia Asp sp | 0.97 (0.59–1.59) | 0.90 | 0.82 (0.60–1.13) | 0.23 | 0.87 (0.66–1.13) | 0.28 |
*
Joined cohort multivariable model also adjusted for center.
Abbreviations: CF: cystic fibrosis. Txp: transplant. ATG: anti-thymocyte globulin. AR: acute rejection. BOS: bronchiolitis obliterans syndrome. CMV: cytomegalovirus. CARV: community acquired respiratory virus. Asp sp: Aspergillus species.