Table 3.
Genetic locations and multipoint P values (Haseman-Elston and empirical) for Chr17 locus demonstrating genome-wide suggestive linkage (P ≤ 0.00074) for fibromyalgia
| Chromosome | Marker | Cytogenic location |
Position (cM) |
Position (hg19) |
Nominal P value |
Empirical P value** |
|---|---|---|---|---|---|---|
| 17 | 40.0 | 0.00071* | 0.00044* | |||
| 17 | 42.0 | 0.00043* | 0.00036* | |||
| 17 | D17S2196 | 17p11.2 | 44.0 | ~17,264kb | 0.00033* | 0.00030* |
| 17 | 46.0 | 0.00025* | 0.00020* | |||
| 17 | 48.0 | 0.00029* | 0.00026* | |||
| 17 | D17S1294 | 17q11.2 | 50.0 | ~28,382kb | 0.00048* | 0.00035* |
P<0.00074, the Lander and Kruglyak’s criteria for genome-wide suggestive linkage.
Empirical P values were obtained through 100,000 permutations.