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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Epilepsia. 2013 Feb 14;54(4):649–657. doi: 10.1111/epi.12121

Figure 1. Exogenous MG attenuates picrotoxin-induced seizures at the behavioral level.

Figure 1

B6 mice were pre-treated with vehicle or MG (50 and 200 mg/kg) prior to seizure induction with picrotoxin (5 mg/kg). a, MG pre-treatment increased the latency to first generalized convulsion. P = 0.0002 by Kruskal-Wallis test. b, MG pre-treatment reduced the duration of generalized convulsions. P = 0.0025 by Kruskal-Wallis test. c, MG pre-treatment reduced the percentage of animals undergoing generalized convulsions. P = 0.0033 by Kruskal-Wallis test.

Data are mean ± SEM. n = 16 vehicle, 8 MG (50 mg/kg), 10 MG (200 mg/kg). * P < 0.05, ** P < 0.005 versus vehicle-treated group as determined by Mann-Whitney U tests.