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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Cancer Res. 2013 Feb 4;73(7):2199–2210. doi: 10.1158/0008-5472.CAN-12-4400

Figure 7. DPP3 expression positively associates with NRF2 activity in squamous cell lung cancer.

Figure 7

(A) DPP3 mRNA abundance in 175 squamous cell lung carcinomas and 27 matched normal tissues (p=4.601e-14; Kruskal-Wallis test). Normal or lung SQCC subtype is indicated by color. With respect to tumor subtype, DPP3 is over-expression is enriched within the primitive subtype (p=0.03334; Kruskal-Wallis test; see also Figure S2). (B) DPP3 mRNA expression positively correlates with DPP3 genomic copy number (Spearman rank correlation). (C) Correlation of DPP3 mRNA expression with NRF2 mutational status (p=0.00141; Kruskal-Wallis test). (D) Correlation of DPP3 mRNA expression with KEAP1 mutational status (p=0.03718; Kruskal-Wallis test). (E and F) HEK293T cells were transiently transfected with NQO1-ARE-luciferase reporter, constitutively active Renilla reporter and the indicated expression plasmids (* P<0.05 across at least three biological triplicate experiments) (G) DPP3 mRNA expression positively associates with NRF2 target gene expression (Spearman rank correlation test). The NRF2 gene signature consists of 15 genes (3). Triangles represent tumors with NRF2 mutations. (See also Figure S2 and S3).