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Level of mutant JAK2 V617F allele frequency in granulocytes does not correlate with response to inhibition of phosphoSTAT5
| Stratified byJAK2 V617F allele freq | Mean allele freq (%) | Mean % pSTAT5 AT 20μM | n |
|---|---|---|---|
|
All patients with JAK2 V617 mutation
| |||
| < 50% | 17 | 49.6 | 5 |
| > 50% | 74 | 48.6 | 11 |
|
| |||
|
Polycythemia Vera/Essential Thrombocytosis
| |||
| < 50% | 31 | 4.05 | 2 |
| > 50% | 75 | 35.74 | 7 |
|
| |||
|
Myelofibrosis
| |||
| < 50% | 8 | 80.03 | 3 |
| > 50% | 73 | 71.02 | 4 |
