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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Pharm Res. 2013 Jan 15;30(5):1240–1251. doi: 10.1007/s11095-012-0963-6

Figure 7.

Figure 7

Representative microscopic images of H&E-stained intestinal villi following treatment with vehicle or two doses of CA-lys-TFA. Intestinal villi from vehicle- and low-dose (150 mg/kg) CA-lys-TFA -treated mice show intact surface epithelium at the tips of small intestinal villi. In contrast, in two of three mice treated with high-dose (300 mg/kg) CA-lys-TFA cellular injury at the tips of intestinal villi was observed (lower, right panel). Villus injury in mice treated with high-dose CA-lys-TFA is characterized by loss of nuclei and cytoplasmic vacuolization in a few cells (thick arrow). Confluent necrosis of the epithelial tip lining with early sloughing toward the lumen is noted in adjacent villi marked with thin arrows. Size bars = 100 micrometers.