Table I.

Significantly downregulated proteins in metastatic lung tumors after treatment of Celecoxib, Docetaxel, or in combination

Accession	# AAs	MW [kDa]	calc. pI	Description	Fold Change Cxb/Ctrl	t-test (p values)	Fold Change Doc/Ctrl	t-test (p values)	Fold Change Combo/Ctrl	t-test (p values)
IPI00013895	105	11.7	7.12	Protein S100-A11	−2.00	0.001192	−2.06	0.00019	−1.67	0.00504
IPI00016179	98	11.5	6.16	Protein S100-A13	−1.56	0.013084	−1.36	0.00619	−1.74	0.00655
IPI00010214	104	11.7	5.24	Protein S100-A14	−2.06	0.001781	−1.27	0.00924	−1.52	0.01095
IPI00062120	103	11.8	6.79	Protein S100-A16	−2.35	0.000120	−2.98	0.00007	−1.81	0.02407
IPI00032313	101	11.7	6.11	Protein S100-A4	−3.22	0.000637	−2.95	0.00050	−2.47	0.00250
IPI00027463	90	10.2	5.48	Protein S100-A6	−2.14	0.000582	−1.57	0.00132	−2.46	0.00229
IPI00017526	95	10.4	4.88	Protein S100-P	−1.42	0.006295	−1.18	0.11675	−1.59	0.01736
IPI00008527	114	11.5	4.32	60S acidic ribosomal protein P1	−6.33	0.001264	−6.67	0.00181	ND
IPI00008529	115	11.7	4.54	60S acidic ribosomal protein P2	−1.50	0.000109	−1.32	0.01327	−1.36	0.00631
IPI00942032	175	20.0	9.00	AGR2	−4.95	0.000125	−2.66	0.00014	−5.65	0.00062
IPI00554648	483	53.7	5.59	Keratin, type II cytoskeletal 8	−4.78	0.000106	−2.97	0.00009	−3.52	0.00140
IPI00418471	466	53.6	5.12	Vimentin	−3.09	0.000144	−1.44	0.00003	−3.02	0.00128
IPI00219219	135	14.7	5.50	Galectin-1	−2.82	0.002144	−1.50	0.00012	−1.16	0.05178
IPI00012011	166	18.5	8.09	Cofilin-1	−2.79	0.000365	−1.79	0.00038	−2.05	0.01166
IPI00645674	108	12.5	4.82	Glutathione S-transferase A3	−2.31	0.009014	−1.19	0.03458	ND
IPI00550363	199	22.4	8.25	Transgelin-2	−2.01	0.000376	−1.32	0.00053	−1.64	0.00419
IPI00022283	84	9.1	4.35	Trefoil factor 1	−1.68	0.005099	−1.91	0.00447	−1.22	0.01276
IPI00015894	356	38.0	5.19	Cdc42 effector protein 4	−1.36	0.041237	−1.14	0.01753	ND
IPI00298547	189	19.9	6.79	Protein DJ-1	−2.14	0.000770	−1.38	0.00090	−2.01	0.00111
IPI00917753	265	31.0	4.23	SET nuclear oncogene	−3.28	0.000058	−0.99	0.92124	−1.92	0.01838