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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Gene Ther. 2013 Jan 10;20(4):450–459. doi: 10.1038/gt.2012.101

Figure 1. AAV2.5 can cross the ependymal cell barrier and transduce neurons after ventricular administration.

Figure 1

AAV2.5/GFP (10 uL, 6.6×1010 vg) was injected into the anterior portion of the right lateral ventricle of adult rats, and after 2 weeks gene expression was assessed by anti-GFP IHC. (A) Transduction of cells with neuronal morphology in the hypothalamus along the third ventricle. (B) GFP-positive cells with neuronal morphology in the dorsal central gray. Scale bar is 50 microns.