FIG. 5.
Glucose toxicity in C57BL/6 and human islets. Islets of wild-type C57BL/6 mice (A) or isolated human islets (B) were incubated at low (5 mmol/l) or high (25 mmol/l) glucose for 24 h and then analyzed by TUNEL. At least seven different islets were analyzed per group and condition and >1,000 mouse or human β-cell nuclei were evaluated. Bars represent means ± SE.