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Recognition of SAM (pink carbon backbone) by the SAM-I subfamily (green carbon backbone). (a) Interaction of the adenine moiety with nucleotides in P3 (A45 and U57) to form a base triple. (b) The main chain atoms of methionine form hydrogen-bonding interactions with the P3 helix (G58) and J1/2 (G11). (c) Electrostatic interaction between the sulfonium ion of SAM (yellow sphere) and two carbonyl oxygens (red spheres) in the P1 helix.
