. Author manuscript; available in PMC: 2014 Feb 5.

Published in final edited form as: Chem Res Toxicol. 2012 Dec 26;26(1):156–168. doi: 10.1021/tx300437x

Table 1.

Minor (3-mA) and major (7-mG) groove adduct production (pmol/μg DNA) from the reaction of 1 and 7 with CT-DNA.^a

compound concentration	1	7	1	7	1	7	1	7
compound concentration	1 μM		5 μM		10 μM		100 μM
3-mA	7.15	13.11	24.36	38.04	25.55	62.08	232.14	365.27
7-mA	0.04	0.13	0.13	0.22	0.43	0.39	3.56	3.13
3-mA/7-mG	179	101	187	173	59	159	65	117

Reactions conditions: 24 h incubation of compounds with CT-DNA (100 μM, p) at room temperature in 10 mM sodium phosphate buffer (pH 7.0). Data is based on HPLC analysis with UV detection.