Table 2.

A 35-year follow-up with subdistribution hazard ratio (95% CI) adjusted for age for coronary heart disease and stroke with regard to individual risk factors at baseline

Risk factors	Number at risk	Eventsa	Total observation years	IRRb (95% CI)	Adjusted SHRb (95% CI)
CHD (mmol/L)
S-cholesterol
<5.0	703	180	18 000	1 (ref)	1 (ref)
5.0–5.9	1986	543	51 090.5	1.08 (0.91–1.27)	1.10 (0.93–1.30)
6.0–6.9	2364	818	57 901.9	1.45 (1.24–1.71)	1.50 (1.28–1.76)
≥7.0	2121	876	48 799	1.86 (1.58–2.19)	1.93 (1.65–2.26)
SBP (mmHg)
<140	2552	692	66 570.9	1 (ref)	1 (ref)
140–159	2573	878	63 377	1.31 (1.18–1.45)	1.31 (1.19–1.45)
≥160	2049	847	45 843.5	1.72 (1.55–1.90)	1.68 (1.52–1.86)
Smoking
Non-smoker	3577	1112	95 528.8	1 (ref)	1 (ref)
Smoking	3597	1305	80 262.6	1.38 (1.27–1.49)	1.26 (1.16–1.36)
Hypertension
Non-hypertensive	2171	568	57 501.2	1 (ref)	1 (ref)
Hypertensive	5003	1849	11 8290	1.54 (1.40–1.69)	1.51 (1.38–1.66)
Antihypertensive medication	367	166	7794.7	1.56 (1.33–1.83)	1.55 (1.31–1.82)
Stroke (mmol/L)
S-cholesterol
<5.0	703	128	18 031.4	1 (ref)	1 (ref)
5.0–5.9	1986	353	52 106.9	0.97 (0.79–1.18)	0.99 (0.81–1.21)
6.0–6.9	2364	457	60 870.4	1.09 (0.89–1.32)	1.09 (0.90–1.33)
≥7.0	2121	397	52 590.5	1.10 (0.90–1.35)	1.06 (0.87–1.30)
SBP (mmHg)
<140	2552	418	68 831.8	1 (ref)	1 (ref)
140–159	2573	468	66 617.5	1.13 (0.99–1.29)	1.11 (0.97–1.26)
≥160	2049	449	48 149.9	1.48 (1.29–1.69)	1.37 (1.20–1.57)
Smoking
Non-smoker	3577	715	98 698.1	1 (ref)	1 (ref)
Smoking	3597	620	84 901.1	0.99 (0.89–1.11)	0.86 (0.77–0.95)
Hypertension
Non-hypertensive	2171	341	59 374.1	1 (ref)	1 (ref)
Hypertensive	5003	994	12 4225	1.35 (1.19–1.53)	1.28 (1.13–1.44)
Antihypertensive medication	367	85	8131.4	1.43 (1.15–1.79)	1.31 (1.05–1.65)

^aFirst ever occurrence of a CHD or stroke.

^bAge-adjusted incidence ratio (IRR) and subdistribution hazard ratio (SHR).