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Effect of magnolol on RANKL-induced bone resorption of mature osteoclasts in vitro. RAW 264.7 cells were incubated with various concentrations of magnolol (5–20 μM) in the presence of RANKL (50 ng/mL). (a) For the visualization of pits formation, the resorption area was analyzed by a microscope. (b) The percentage of resorption area caused by osteoclasts was measured. Data are expressed as the mean ± SD (n = 4). **P < 0.01, ***P < 0.001 versus RANKL-treated alone group.
