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. Author manuscript; available in PMC: 2013 Apr 7.
Published in final edited form as: Gastroenterology. 2011 Dec 16;142(4):918–927.e6. doi: 10.1053/j.gastro.2011.12.017

Figure 3. Both VEGF-independent of NO plus VEGF-stimulated NO are required to maintain normal LSEC fenestration.

Figure 3

LSEC cultured with VEGF+L-NAME (top left panel) or DETA-NONOate (NO donor; top right panel) for 2 days lack fenestration, while LSEC cultured with VEGF+L-NAME+DETA-NONOate (bottom left panel) for 2 days demonstrate normal fenestration. Porosity is shown in the bottom right panel. Scale bar, 5μm. * p<0.001versus VEGF control; NS, not significant; n = 3.