Table 1.
Statistical results of group main effects and interactions for resting EEG (A) and sensory gating (B). All mean and s.e. values are presented at Figure 2. “Group” is group main effect among patients, relatives, and controls. All analyses in the table used age and gender as covariates. In 3-way tests, p value threshold for significance were adjusted to 0.05 for resting EEG and 0.017 (0.05/3) for sensory gating to account for 3 tests of S1, S2, and S2/S1 ratio. Only interactions related to frequency and group are presented here given that these are related to the primary aims. In the 2-way tests, threshold p values for main effects and interactions were 0.0083 (0.05/6), to account for testing 6 frequency bands. Note theta-alpha is the only frequency band showing group effect across all conditions. Significant findings after Bonferroni corrections are shown in bold.
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A: Resting EEG Oscillations Statistics
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3-way Tests (freq x channel x group) |
2-way Tests (channel x group) |
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| Event | Group Effect |
Freq. × Group |
Freq. × Channel × Group |
High gamma (>85 Hz) |
Gamma (40-85 Hz) |
Low gamma (20-40 Hz) |
Beta (12-20 Hz) |
Theta-alpha (5-11 Hz) |
Delta (1-4 Hz) |
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| Group Effect |
Group × Channel |
Group Effect |
Group × Channel |
Group Effect |
Group × Channel |
Group Effect |
Group × Channel |
Group Effect |
Group × Channel |
Group Effect |
Group × Channel |
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| n/a | F | 7.69 | 4.97 | 1.12 | 3.29 | 1.20 | 4.88 | 2.43 | 1.86 | 1.88 | 2.75 | 1.2 | 16.25 | 1.48 | 12.7 | 0.96 |
| p | [0.001] | [0.001] | 0.20 | 0.04 | 0.28 | [0.008] | 0.006 | 0.16 | 0.03 | 0.07 | 0.28 | [0.000] | 0.15 | [0.000] | 0.48 | |
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B: Sensory Gating Oscillations Statistics
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| Ratio | F | 3.05 | 6.29 | 1.45 | 2.12 | 0.73 | 4.24 | 2.57 | 4.97 | 2.47 | 0.95 | 1.62 | 10.9 | 1.62 | 10.72 | 1.06 |
| p | 0.05 | [0.000] | [0.013] | 0.12 | 0.75 | 0.02 | 0.01 | [0.008] | [0.002] | 0.39 | 0.07 | [0.000] | 0.048 | [0.000] | 0.39 | |
| S1 | F | 5.78 | 2.23 | 1.74 | 7.20 | 2.71 | 5.10 | 2.56 | 2.17 | 2.62 | 5.32 | 1.09 | 6.13 | 1.77 | 1.59 | 1.96 |
| p | [0.003] | 0.05 | [0.017] | [0.001] | [0.004] | [0.007] | 0.009 | 0.12 | [0.004] | [0.005] | 0.37 | [0.002] | 0.09 | 0.21 | 0.06 | |
| S2 | F | 7.16 | 3.54 | 2.24 | 6.98 | 2.29 | 4.60 | 2.63 | 2.46 | 2.60 | 4.80 | 0.90 | 13.52 | 2.46 | 7.95 | 2.26 |
| p | [0.001] | [0.005] | [0.001] | [0.001] | 0.02 | 0.01 | [0.006] | 0.09 | [0.004] | 0.009 | 0.57 | [0.000] | 0.01 | [0.001] | 0.03 | |